New regulators of ribosome biogenesis, transcription, and mitochondrial respiration were discovered, including CCDC86, ZNF236, and SPATA5L1.
Mapping information-rich genotype-phenotype landscapes ... - PMC 210K Mixed.txt
The study allows for in-depth dissection of complex cellular phenomena, including RNA processing and differentiation. New regulators of ribosome biogenesis
This multi-dimensional portrait of gene function enables researchers to map the relationship between genotypes and phenotypes, providing a valuable resource for identifying genetic drivers of complex cellular behaviors. How compares to traditional gene editing? The mitochondrial genome findings in more detail? and mitochondrial respiration were discovered
Mapping the Human Cellular Landscape: A 2.5-Million Cell Odyssey
The research uses transcriptional phenotypes to predict the function of poorly characterized genes.