: Enrichment of dilute samples to ensure they are within the detection range of highly sensitive instruments. Role in Mass Spectrometry
A C4 ZipTip is a standard pipette tip containing a microscopic bed of resin fixed at its distal end. Unlike C18 resins, which are used for smaller peptides, the C4 resin is optimized for larger, more hydrophobic molecules like proteins and large polypeptides. Primary Uses in Research Researchers use these tools for two main reasons: c4.zip
Expression, Purification and Characterization of the Human ... - Nature : Enrichment of dilute samples to ensure they
: Removing salts, buffers, and detergents that interfere with downstream analysis. For example, researchers use them to clean samples of Trastuzumab probes or mussel biotoxins before testing. Primary Uses in Research Researchers use these tools
This technology has been instrumental in recent studies, including identifying SARS-CoV-2 protease cleavage sites and characterizing human cannabinoid receptors.
: Best for proteins > 10 kDa and highly hydrophobic peptides.