The U.S. is unique in its treatment of DHEA as a supplement; most other developed nations regulate it as an anabolic steroid or a prescription drug. Regulation Status

: While oral DHEA is OTC in the U.S., some specific medical forms, such as the vaginal insert Intrarosa (prasterone) used for menopause symptoms, require a prescription.

Because DHEA is classified as a dietary supplement by the FDA rather than a drug, it does not require a prescription and is not a controlled substance under the Controlled Substances Act.

: DHEA is a precursor to estrogen and testosterone. Experts recommend consulting a doctor before use, especially if you have a history of hormone-sensitive cancers (breast, ovarian, or prostate).

: DHEA is a prohibited anabolic agent under the World Anti-Doping Agency (WADA) Prohibited List. It is banned at all times for competitive athletes in the Olympics, NCAA, NFL, and NBA.