Never drink or sell Nuka-Cola or Nuka-Cola Quantum. Save them for the Nuka-Cola Challenge quest later.
Keep Charisma at 1. Speech can easily be leveled up manually without wasting precious S.P.E.C.I.A.L. points. fallout-3-game-of-the-year-edition
Leave room for the stat-boosting Bobbleheads scattered across the Capital Wasteland. Never drink or sell Nuka-Cola or Nuka-Cola Quantum