Gigp-40.mp4 May 2026

Glycogen-Dependent Glycolytic Plasticity in Neuronal Function (GDGP)

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Glycogen serves as a direct fuel source to sustain glycolytic plasticity and synaptic function in vivo. The inability to utilize GDGP is associated with deficiencies in synaptic vesicle recycling during hypoxia. However, evidence now indicates that neurons can engage

Traditionally, neurons were thought to rely primarily on blood-glucose-derived glucose, with astrocytes managing glycogen storage. However, evidence now indicates that neurons can engage in their own glycogen-dependent glycolytic plasticity (GDGP) to meet sudden metabolic demands. This paper investigates how GDGP operates, specifically in mitigating the effects of mitochondrial dysfunction. Findings on GDGP Mechanisms GDGP becomes critical during conditions of transient hypoxia

-related research (such as cell-level studies or related data).

GDGP becomes critical during conditions of transient hypoxia or mitochondrial dysfunction, acting as a backup fuel source to sustain synaptic vesicle recycling.

Neurons regulate glycolysis dynamically in response to metabolic stress.