'Grey's Anatomy' Season 12 Trailer: "Everything Has Changed"
: Meredith Grey adjusts to life as a widow, moving back into her mother's house with her "sisters," Maggie Pierce and Amelia Shepherd. A major mid-season arc involves Meredith being brutally attacked by a patient, leading to a long recovery and therapy.
: Their developing romance culminates in a wedding in the season finale, though Amelia initially has doubts and runs away before the ceremony. Greys Anatomy - Season 12
: This season marked the final regular appearance of Sara Ramirez as Callie Torres. Reception & Ratings
: Tension peaks when Callie’s new girlfriend, Penny, is revealed to be one of the doctors who failed to save Derek. Penny eventually joins the hospital as a resident, causing friction with Meredith and Amelia. Relationship Turmoil : 'Grey's Anatomy' Season 12 Trailer: "Everything Has Changed"
: The couple's marriage collapses, leading to a divorce. However, they discover April is pregnant shortly before signing the papers.
: Alex proposes multiple times, but Jo repeatedly declines because she is secretly still married to an abusive man she fled years prior. Cast Transitions : This season marked the final regular appearance
: Martin Henderson joined the cast as Dr. Nathan Riggs, whose arrival triggers a dark history for Owen Hunt involving his missing sister.