The Bills historically hold the upper hand in this series, which began in 1972. The Bills lead 8-4-1.
How Lions and Bills match up ahead of game of the season - ESPN NFL Buffalo Bills vs Detroit Lions
The Buffalo Bills and Detroit Lions are set to continue their high-octane rivalry as they face off during the upcoming . Both teams are currently considered top-tier Super Bowl contenders, representing two of the league's most explosive offenses led by elite quarterbacks. Latest Matchup Context The Bills historically hold the upper hand in
Buffalo has won four consecutive games against Detroit. NFL Buffalo Bills vs Detroit Lions