[s5e22]: What A Difference A Day Makes

The episode's central plot twist occurs when Meredith and Derek decide to give their meticulously planned wedding to Izzie and Alex.

: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party. [S5E22] What a Difference a Day Makes

: Alex delivers a powerful, spontaneous speech adapted from a valedictorian's graduation address, promising to be accountable to Izzie through any future challenges. Medical Drama and Character Growth The episode's central plot twist occurs when Meredith

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances. Medical Drama and Character Growth : Creator Shonda

: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately.

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to.