The physical distance between the enhancer and the gene's transcription start site.
Captures how multiple enhancers might work together to regulate a single gene. Contextual Meaning of the Name Based on the structure of the string: theagle.Cely.1.var
: Likely refers to the EAGLE tool or its associated database, EnhancerAtlas . The physical distance between the enhancer and the
Measures how closely the activity of an enhancer aligns with the expression patterns of a target gene. Measures how closely the activity of an enhancer
These track the number of other enhancers (EWS) or genes (GWS) located in the "window" between the enhancer and gene of interest, accounting for potential interference or competition.
The most interesting aspect of variables in this system is their ; unlike older models that required dozens of inputs, EAGLE uses only six core features to predict interactions with high accuracy: